Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

@article{Li2000FunctionalLO,
  title={Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response},
  author={Shang Li and Nicholas S. Y. Ting and Lei Zheng and Phang-lang Chen and Yael Ziv and Yosef Shiloh and Eva Y.-H. P. Lee and Wen-Hwa Lee},
  journal={Nature},
  year={2000},
  volume={406},
  pages={210-215}
}
BRCA1 encodes a familial breast cancer suppressor that has a critical role in cellular responses to DNA damage. Mouse cells deficient for Brca1 show genetic instability, defective G2–M checkpoint control and reduced homologous recombination. BRCA1 also directly interacts with proteins of the DNA repair machinery and regulates expression of both the p21 and GADD45 genes. However, it remains unclear how DNA damage signals are transmitted to modulate the repair function of BRCA1. Here we show that… 

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ABSTRACT BRCA1 plays an important role in mechanisms of response to double-strand breaks, participating in genome surveillance, DNA repair, and cell cycle checkpoint arrests. Here, we identify a
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