Functional link between muscarinic receptors and large-conductance Ca2+-activated K+ channels in freshly isolated human detrusor smooth muscle cells

Abstract

Activation of muscarinic acetylcholine receptors (mAChRs) constitutes the primary mechanism for enhancing excitability and contractility of human detrusor smooth muscle (DSM). Since the large-conductance Ca2+-activated K+ (KCa1.1) channels are key regulators of human DSM function, we investigated whether mAChR activation increases human DSM excitability by… (More)
DOI: 10.1007/s00424-014-1537-8

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