Functional level of rat liver tryptophan 2 , 3 - dioxygenase messenger RNA during superinduction of enzyme with actinomycin D ( cell - free protein

Abstract

Tryptophan 2,3-dioxygenase [EC 1.13.11.11; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)] activity is induced by glucocorticoid hormones and superinduced by actinomycin D. Previous experiments had shown that hormonal induction of the enzyme activity is accompanied by parallel increases in tryptophan 2,3-dioxygenase mRNA level. In this study, we… (More)

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