Functional involvement of Xenopus LIM kinases in progression of oocyte maturation.

@article{Takahashi2001FunctionalIO,
  title={Functional involvement of Xenopus LIM kinases in progression of oocyte maturation.},
  author={Toshiki Takahashi and Uichi Koshimizu and Hiroshi Abe and Takashi Obinata and Toshikazu Nakamura},
  journal={Developmental biology},
  year={2001},
  volume={229 2},
  pages={554-67}
}
LIM kinases (LIMK), including LIMK1 and LIMK2, are unique LIM-family proteins containing a catalytic (kinase) domain. These kinases phosphorylate an actin-depolymerizing factor, cofilin, involved in the regulation of actin-filament dynamics. An unanswered question is the in vivo function of LIMK and how they contribute to development. When we cloned Xenopus homologues of mammalian LIMK, Xlimk1 and Xlimk2, we found that their mRNA and products were abundantly expressed in oocytes. In addition… CONTINUE READING
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