Functional investigation of a schizophrenia GWAS signal at the CDC42 gene.

OBJECTIVES SNP rs2473277 upstream of the cell division cycle 42 (CDC42) gene was associated with schizophrenia in a recent genome-wide association study (GWAS). Reduced expression of CDC42 in schizophrenia has previously been reported. Our objective was to test whether the associated SNP affected CDC42 expression. METHODS Two available SNP × gene… CONTINUE READING