Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.

@article{Teng2011FunctionalIB,
  title={Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.},
  author={Yong Teng and Mingyao Liu and John K Cowell},
  journal={International journal of cancer},
  year={2011},
  volume={129 12},
  pages={
          2825-35
        }
}
Loss of WASF3 function in breast cancer cells results in loss of invasion phenotypes and reduced metastatic potential. By using oligonucleotide arrays, we now demonstrate that knockdown of WASF3 leads to the upregulation of the KISS1 metastasis suppressor gene with concomitant reduced invasion and loss of matrix metalloproteinases (MMP)-9 activity. Using a luciferase reporter, KISS1 transcription is significantly increased in the absence of WASF3. Knockdown of KISS1 in WASF3-silenced cells… CONTINUE READING
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