Functional interplay between p53 and E2F through co-activator p300

@article{Lee1998FunctionalIB,
  title={Functional interplay between p53 and E2F through co-activator p300},
  author={Chang-woo Lee and Troels S S\orensen and Noriko Shikama and Nicholas B. La Thangue},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={2695-2710}
}
Both E2F and p53 are sequence specific transcription factors that regulate early cell cycle progression. The pathway of control mediated through E2F governs the transition from G1 into S phase whereas p53 in response to genotoxic stress can facilitate cell cycle arrest or apoptosis. The mechanisms which influence the outcome of p53 induction are not clear, although transcription of the p53 target gene, encoding the cdk-inhibitor p21Waf1/Cip1, correlates with p53-mediated cell cycle arrest. Here… CONTINUE READING
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