Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes

@article{Ramy2009FunctionalIB,
  title={Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes},
  author={Rosy El Ramy and Najat Magroun and Nadia Messadecq and Laurent Robert Gauthier and François Dominique Boussin and Ullas Kolthur-Seetharam and Val{\'e}rie Schreiber and Michael W McBurney and Paolo Sassone-Corsi and Françoise Dantzer},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={66},
  pages={3219-3234}
}
Poly(ADP-ribose) polymerase-1 (Parp-1) and the protein deacetylase SirT1 are two of the most effective NAD+-consuming enzymes in the cell with key functions in genome integrity and chromatin-based pathways. Here, we examined the in vivo crosstalk between both proteins. We observed that the double disruption of both genes in mice tends to increase late post-natal lethality before weaning consistent with important roles of both proteins in genome integrity during mouse development. We identified… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

The role of poly(ADP-ribosyl)ation in epigenetic events

  • D Quenet, R El Ramy, V Schreiber, F Dantzer
  • Int J Biochem Cell Biol
  • 2009
3 Excerpts

Similar Papers

Loading similar papers…