Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation.

@article{Battistelli2014FunctionalIB,
  title={Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation.},
  author={Cecilia Battistelli and Anna Busanello and Rossella Maione},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 17},
  pages={3757-67}
}
Higher-order chromatin structures appear to be dynamically arranged during development and differentiation. However, the molecular mechanism underlying their maintenance or disruption and their functional relevance to gene regulation are poorly understood. We recently described a dynamic long-range chromatin interaction between the gene promoter of the cdk inhibitor p57(kip2) (also known as Cdkn1c) and the imprinting control region KvDMR1 in muscle cells. Here, we show that CTCF, the best… CONTINUE READING
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