Functional interplay between MDM2, p63/p73 and mutant p53

  title={Functional interplay between MDM2, p63/p73 and mutant p53},
  author={Maren H Stindt and Philippe Muller and Ralph Ludwig and Sebastian Kehrloesser and Volker D{\"o}tsch and Karen Heather Vousden},
Many cancers express mutant p53 proteins that have lost wild-type tumor suppressor activity and, in many cases, have acquired oncogenic functions that can contribute to tumor progression. These activities of mutant p53 reflect interactions with several other proteins, including the p53 family members p63 and p73. Mutations in p53 that affect protein conformation (such as R175H) show strong binding to p63 and p73, whereas p53 mutants that only mildly affect the conformation (such as R273H) bind… CONTINUE READING
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