Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes.

@article{Tsuzuki2017FunctionalIR,
  title={Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes.},
  author={Hirofumi Tsuzuki and Yojirou Arinobu and Kohta Miyawaki and Ayako Takaki and Shun-ichiro Ota and Yuri Ota and Hiroki Mitoma and Mitsuteru Akahoshi and Yasuo Mori and Hiromi Iwasaki and Hiroaki Niiro and Hiroshi Tsukamoto and Koichi Akashi},
  journal={Immunology},
  year={2017},
  volume={150 1},
  pages={64-73}
}
Interleukin-33 (IL-33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity-mediated allergic inflammation. Allergy-related innate myeloid cells such as eosinophils, basophils and mast cells express the IL-33 receptor (IL-33R), but it is still unknown how IL-33 regulates allergic inflammation involving these cells and their progenitors. Here, we revealed that the functional IL-33R was expressed on eosinophil… CONTINUE READING
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