Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.

  title={Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.},
  author={Mark E. Ewen and Hayla K. Sluss and Charles J Sherr and Hitoshi Matsushime and Jun-ya Kato and David M. Livingston},
  volume={73 3},
The retinoblastoma gene product (Rb) can interact efficiently with two of three D-type G1 cyclins (D2 and D3) in vitro. Binding depended upon the minimal regions of Rb necessary for its growth-suppressive activity, as well as upon the D-type cyclin sequence motif shared with Rb-binding DNA tumor virus oncoproteins. Coexpression of the three D-type cyclins with the cyclin-dependent kinase (cdk4) in insect cells generated Rb kinase activity. By contrast, cyclins D2 and D3, but not D1, activated… CONTINUE READING
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