Functional interactions between the estrogen receptor and the transcription activator Sp1 regulate the estrogen-dependent transcriptional activity of the vitellogenin A1 io promoter.

@article{Medeiros1997FunctionalIB,
  title={Functional interactions between the estrogen receptor and the transcription activator Sp1 regulate the estrogen-dependent transcriptional activity of the vitellogenin A1 io promoter.},
  author={Silvia Regina Batistuzzo de Medeiros and Grigorios Krey and Abdelmadjid K Hihi and Walter Wahli},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 29},
  pages={18250-60}
}
Two distinct, TATA box-containing promoters regulate the transcriptional activity of the Xenopus vitellogenin A1 gene. These two promoters are of different strength and are separated by 1.8 kilobase pairs of untranslated sequence. Estrogen receptor (ER) and its ligand, 17beta-estradiol, induce the activity of both promoters. The estrogen response elements (EREs) are located proximal to the downstream i promoter while no ERE-like sequences have been identified in the vicinity of the upstream io… CONTINUE READING

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