Functional interactions between YY1 and adenovirus E1A.

  title={Functional interactions between YY1 and adenovirus E1A.},
  author={Jin Sun Lee and Raymond H. See and Katherine M. Galvin and Jia-fu Wang and Yujiang Geno Shi},
  journal={Nucleic acids research},
  volume={23 6},
YY1 is a C2H2-type zinc finger transcription factor that is a member of the human GLl-Kruppel family of proteins. YY1 represses transcription when bound upstream of transcription initiation sites. The repression can be relieved by adenovirus E1A and activation of target genes occurs. We have mapped the repression domain of YY1 to the C-terminal region, overlapping its DNA binding domain. We have also identified an activation domain within the first 69 amino acids of YY1. The YY1 C-terminal… CONTINUE READING