Functional interactions between Stat5 and the glucocorticoid receptor

  title={Functional interactions between Stat5 and the glucocorticoid receptor},
  author={Elisabeth Stoecklin and Manuela Wissler and Fabrice Gouilleux and Bernd Groner},
SIGNAL transduction pathways enable extracellular signals to activate latent transcription factors in the cytoplasm of cells. Dimerization, nuclear localization and binding to specific DNA sequences result in the induction of gene transcription by these proteins. These events are necessary for the functioning of the JAK/STAT pathway and of the glucocorticoid-receptor pathway. In the former, the protein Stat5, which is a member of a family of signal transducers and activators of transcription… CONTINUE READING
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