Functional interactions between P2X4 and P2X7 receptors from mouse salivary epithelia.

@article{CasasPruneda2009FunctionalIB,
  title={Functional interactions between P2X4 and P2X7 receptors from mouse salivary epithelia.},
  author={Griselda Casas-Pruneda and Juan Pablo Reyes and Gabriela P{\'e}rez-Flores and Patricia P{\'e}rez-Cornejo and Jorge Arreola},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 12},
  pages={2887-901}
}
Mouse parotid acinar cells express P2X4 and P2X7 receptors (mP2X4R and mP2X7R) whose physiological function remains undetermined. Here we show that mP2X4R expressed in HEK-293 cells do not allow the passage of tetraethylammonium (TEA+) and promote little, if any, ethidium bromide (EtBr) uptake when stimulated with ATP or BzATP. In contrast, mP2X7R generates slowly decaying TEA+ current, sustained Na+ current and promotes robust EtBr uptake. However, ATP-activated TEA+ current from acinar cells… CONTINUE READING
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