Functional interactions between P-glycoprotein and CYP3A in drug metabolism

@article{Christians2005FunctionalIB,
  title={Functional interactions between P-glycoprotein and CYP3A in drug metabolism},
  author={U. Christians and V. Schmitz and M. Haschke},
  journal={Expert Opinion on Drug Metabolism & Toxicology},
  year={2005},
  volume={1},
  pages={641 - 654}
}
  • U. Christians, V. Schmitz, M. Haschke
  • Published 2005
  • Medicine, Biology
  • Expert Opinion on Drug Metabolism & Toxicology
  • The interaction between drug-metabolising enzymes and active transporters is an emerging concept in pharmacokinetics. In the gut mucosa, P-glycoprotein and cytochrome P450 (CYP)3A functionally interact in three ways: i) drugs are repeatedly taken up and pumped out of the enterocytes by P-glycoprotein, thus increasing the probability of drugs being metabolised; ii) P-glycoprotein keeps intracellular drug concentrations within the linear range of the metabolising capacity of CYP3A; and iii) P… CONTINUE READING
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