Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila.

  title={Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila.},
  author={Sujatha Krishnakumar and Doris Burton and Jane F. Rasco and Xiuyin Chen and Janis O'donnell},
  journal={Journal of neurogenetics},
  volume={14 1},
Tyrosine hydroxylase requires the regulatory cofactor, tetrahydrobiopterin, for catecholamine biosynthesis. Because guanosine triphosphate cyclohydrolase I is the rate limiting enzyme for the synthesis of this cofactor, it has a key role in catecholamine production. We show that GTP cyclohydrolase and tyrosine hydroxylase (TH) are co-localized in the Drosophila central nervous system. Mutations in the Punch locus, which encodes GTP cyclohydrolase, reduce TH activity; addition of cofactor to… CONTINUE READING


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