Functional interactions between BLM and XRCC3 in the cell

@article{Otsuki2007FunctionalIB,
  title={Functional interactions between BLM and XRCC3 in the cell},
  author={Makoto Otsuki and Masayuki Seki and Eri Inoue and Akari Yoshimura and Genta Kato and Saki Yamanouchi and Yoh-ichi Kawabe and Shusuke Tada and Akira Shinohara and Jun-ichiro Komura and Tetsuya Ono and Shunichi Takeda and Yutaka Ishii and Takemi Enomoto},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={53 - 63}
}
Bloom's syndrome (BS), which is caused by mutations in the BLM gene, is characterized by a predisposition to a wide variety of cancers. BS cells exhibit elevated frequencies of sister chromatid exchanges (SCEs), interchanges between homologous chromosomes (mitotic chiasmata), and sensitivity to several DNA-damaging agents. To address the mechanism that confers these phenotypes in BS cells, we characterize a series of double and triple mutants with mutations in BLM and in other genes involved in… CONTINUE READING
7 Citations
40 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 40 references

2006a. Bloom helicase and DNA topoisomerase IIIα are involved in the dissolution of sister chromatids

  • M. Seki, T. Nakagawa, +7 authors M. Otsuki
  • 2006
3 Excerpts

Similar Papers

Loading similar papers…