Functional interactions between BLM and XRCC3 in the cell

  title={Functional interactions between BLM and XRCC3 in the cell},
  author={Makoto Otsuki and Masayuki Seki and Eri Inoue and Akari Yoshimura and Genta Kato and Saki Yamanouchi and Yoh-ichi Kawabe and Shusuke Tada and Akira Shinohara and Jun-ichiro Komura and Tetsuya Ono and Shunichi Takeda and Yutaka Ishii and Takemi Enomoto},
  journal={The Journal of Cell Biology},
  pages={53 - 63}
Bloom's syndrome (BS), which is caused by mutations in the BLM gene, is characterized by a predisposition to a wide variety of cancers. BS cells exhibit elevated frequencies of sister chromatid exchanges (SCEs), interchanges between homologous chromosomes (mitotic chiasmata), and sensitivity to several DNA-damaging agents. To address the mechanism that confers these phenotypes in BS cells, we characterize a series of double and triple mutants with mutations in BLM and in other genes involved in… CONTINUE READING
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2006a. Bloom helicase and DNA topoisomerase IIIα are involved in the dissolution of sister chromatids

  • M. Seki, T. Nakagawa, +7 authors M. Otsuki
  • 2006
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