Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein.

@article{Takahashi2000FunctionalIO,
  title={Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein.},
  author={Satoru Takahashi and Hideki Wakui and J A Gustafsson and Johanna Zilliacus and Hirotaka Itoh},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={274 1},
  pages={87-92}
}
Mizoribine (MIZ) is a novel imidazole nucleoside with immunosuppressive activity. MIZ has been approved in Japan and combination therapy with MIZ and glucocorticoids has been used after renal transplantation and for lupus nephritis and rheumatoid arthritis. In this study, we identify 14-3-3 proteins as MIZ-binding proteins. 14-3-3 proteins interact with many proteins involved in cellular signaling, including the glucocorticoid receptor (GR). The 14-3-3/GR interaction enhances the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…