Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.

@article{Wiser1996FunctionalIO,
  title={Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels.},
  author={Ofer Wiser and M. K. Bennett and Daphne Atlas},
  journal={The EMBO journal},
  year={1996},
  volume={15 16},
  pages={4100-10}
}
We have used an electrophysiological assay to investigate the functional interaction of syntaxin 1A and SNAP-25 with the class C, L-type, and the class B, N-type, voltage-sensitive calcium channels. Co-expression of syntaxin 1A with the pore-forming subunits of the L- and N-type channels in Xenopus oocytes generates a dramatic inhibition of inward currents (>60%) and modifies the rate of inactivation (tau) and steady-state voltage dependence of inactivation. Syntaxin 1-267, which lacks the… CONTINUE READING

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