Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters.

  title={Functional interaction of GATA1 with erythroid Kr{\"u}ppel-like factor and Sp1 at defined erythroid promoters.},
  author={Richard C. Gregory and Debra J. Taxman and Dhaya Seshasayee and Margaret Kensinger and James J Bieker and Don M. Wojchowski},
  volume={87 5},
GATA and CACC elements commonly are codistributed within the regulatory domains of a variety of erythroid genes. Using Drosophila S2 cells, the actions of GATA1, Sp1, and erythroid Kruppel-like factor (EKLF) at these elements within model erythroid promoters have been assessed. For each promoter studied (erythroid pyruvate kinase, glycophorin B, and a murine betamaj globin-derived construct, GCT) Sp1 and EKLF each activated transcription despite differences in CACC element sequence, orientation… CONTINUE READING


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