Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.

@article{Massinen2009FunctionalIO,
  title={Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.},
  author={Satu Massinen and Kristiina Tammimies and Isabel Tapia-P{\'a}ez and Hans Matsson and Marie-Estelle Hokkanen and Ola S{\"o}derberg and Ulf Landegren and Eero Castr{\'e}n and Jan-{\AA}ke Gustafsson and Eckardt Treuter and Juha Kere},
  journal={Human molecular genetics},
  year={2009},
  volume={18 15},
  pages={2802-12}
}
Dyslexia, or specific reading disability, is the unexpected failure in learning to read and write when intelligence and senses are normal. One of the susceptibility genes, DYX1C1, has been implicated in neuronal migration, but little is known about its interactions and functions. As DYX1C1 was suggested to interact with the U-box protein CHIP (carboxy terminus of Hsc70-interacting protein), which also participates in the degradation of estrogen receptors alpha (ERalpha) and beta (ERbeta), we… CONTINUE READING

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