Functional interaction of Aurora-A and PP2A during mitosis.

  title={Functional interaction of Aurora-A and PP2A during mitosis.},
  author={Virginie Horn and Jacques Th{\'e}lu and Alphonse Garc{\'i}a and Corinne Albiges-Rizo and Marc R. Block and Jean P Viallet},
  journal={Molecular biology of the cell},
  volume={18 4},
Entry into mitosis is a highly regulated process, promoted by the activated Cyclin B1/Cdk1 complex. Activation of this complex is controlled, in part, by the protein kinase Aurora-A, which is a member of a multigenic serine/threonine kinase family. In normal cells, Aurora-A activity is regulated, at least in part, by degradation through the APC-ubiquitin-proteasome pathway. It has recently been proposed that, in Xenopus, Aurora-A degradation can be inhibited by phosphorylation. It would thus be… CONTINUE READING
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