Functional interaction between the transcription factor Krüppel-like factor 5 and poly(ADP-ribose) polymerase-1 in cardiovascular apoptosis.

@article{Suzuki2007FunctionalIB,
  title={Functional interaction between the transcription factor Kr{\"u}ppel-like factor 5 and poly(ADP-ribose) polymerase-1 in cardiovascular apoptosis.},
  author={T. Suzuki and Toshiya Nishi and Tomoko Nagino and Kana Sasaki and Kenichi Aizawa and Nanae Kada and Daigo Sawaki and Yoshiko Munemasa and Takayoshi Matsumura and Shinsuke Muto and Masataka Sata and Kiyoshi Miyagawa and Masami Horikoshi and Ryozo Nagai},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 13},
  pages={9895-901}
}
Krüppel-like factor 5 (KLF5) is a transcription factor important in regulation of the cardiovascular response to external stress. KLF5 regulates pathological cell growth, and its acetylation is important for this effect. Its mechanisms of action, however, are still unclear. Analysis in KLF5-deficient mice showed that KLF5 confers apoptotic resistance in vascular lesions. Mechanistic analysis further showed that it specifically interacts with poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear… CONTINUE READING
Highly Cited
This paper has 21 citations. REVIEW CITATIONS