Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

  title={Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.},
  author={Françoise Dantzer and Marie-Jos{\`e}phe Giraud-Panis and Isabel Jaco and J C Am{\'e} and I. H. Schultz and Mar{\'i}a Blasco and Catherine-Elaine Koering and Eric Gilson and Josiane M{\'e}nissier-de Murcia and Gilbert de Murcia and Val{\'e}rie Schreiber},
  journal={Molecular and cellular biology},
  volume={24 4},
The DNA damage-dependent poly(ADP-ribose) polymerase-2 (PARP-2) is, together with PARP-1, an active player of the base excision repair process, thus defining its key role in genome surveillance and protection. Telomeres are specialized DNA-protein structures that protect chromosome ends from being recognized and processed as DNA strand breaks. In mammals, telomere protection depends on the T(2)AG(3) repeat binding protein TRF2, which has been shown to remodel telomeres into large duplex loops… CONTINUE READING
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