Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile

Abstract

Cyclooxygenase-2 (Cox-2) is rapidly expressed by various stimuli and plays a key role in conversion of free arachidonic acid to prostaglandins. We have previously identified 4-hydroxy-2-nonenal (HNE), a lipid peroxidation-derived electrophile, as the potent Cox-2 inducer in rat epithelial RL34 cells and revealed that the HNE-induced Cox-2 expression… (More)
DOI: 10.1016/j.redox.2014.11.011

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