Functional interaction between Lypd6 and nicotinic acetylcholine receptors

  title={Functional interaction between Lypd6 and nicotinic acetylcholine receptors},
  author={Maria Jensen Arvaniti and Majbrit Myrup Jensen and Neeraj Soni and Hong Wang and Anders Bue Klein and Nathalie Thiriet and Lars H. Pinborg and Pretal P Wienecke Muldoon and Jacob Wienecke and M Imad Damaj and Kristi A Kohlmeier and Marjorie C. Gondr{\'e}‐Lewis and Jens Damsgaard Mikkelsen and Morten Sk\ott Thomsen},
  booktitle={Journal of neurochemistry},
Nicotinic acetylcholine receptors (nAChRs) affect multiple physiological functions in the brain and their functions are modulated by regulatory proteins of the Lynx family. Here, we report for the first time a direct interaction of the Lynx protein LY6/PLAUR domain-containing 6 (Lypd6) with nAChRs in human brain extracts, identifying Lypd6 as a novel regulator of nAChR function. Using protein cross-linking and affinity purification from human temporal cortical extracts, we demonstrate that… CONTINUE READING
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