Functional interaction between DNA-PK and c-Abl in response to DNA damage

  title={Functional interaction between DNA-PK and c-Abl in response to DNA damage},
  author={Surender Kharbanda and Pramod Pandey and Shengfang Jin and Satoshi Inoue and Ayush Bharti and Zhi-Min Yuan and Ralph Weichselbaum and David E. Weaver and Donald Kufe},
How DNA damage is converted into intracellular signals that can control cell behaviour is unknown. The c-Abl protein tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents1–5, whereas the DNA-dependent protein kinase (DNA-PK), consisting of a serine/threonine kinase and Ku DNA-binding subunits, requires DNA double-strand breaks or other DNA lesions for activation6–8. Here we demonstrate that c-Abl interacts constitutively with DNA-PK. Ionizing radiation… CONTINUE READING
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