Functional integration of embryonic stem cell-derived neurons in vivo.

@article{Wernig2004FunctionalIO,
  title={Functional integration of embryonic stem cell-derived neurons in vivo.},
  author={Marius Wernig and Felix Benninger and Tanja Schmandt and Monika Rade and Kerry Lee Tucker and Heinrich B{\"u}ssow and Heinz Beck and Oliver Bruestle},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 22},
  pages={
          5258-68
        }
}
Pluripotency and the potential for continuous self-renewal make embryonic stem (ES) cells an attractive donor source for neuronal cell replacement. Despite recent encouraging results in this field, little is known about the functional integration of transplanted ES cell-derived neurons on the single-cell level. To address this issue, ES cell-derived neural precursors exhibiting neuron-specific enhanced green fluorescent protein (EGFP) expression were introduced into the developing brain. Donor… CONTINUE READING

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