Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.

@article{Benninger2003FunctionalIO,
  title={Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.},
  author={Felix Benninger and Heinz Beck and Marius Wernig and Kerry Lee Tucker and Oliver Bruestle and Bjoern Scheffler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 18},
  pages={
          7075-83
        }
}
The generation of neurons and glia from pluripotent embryonic stem (ES) cells represents a promising strategy for the study of CNS development and repair. ES cell-derived neural precursors have been shown to develop into morphologically mature neurons and glia when grafted into brain and spinal cord. However, there is a surprising shortage of data concerning the functional integration of ES cell-derived neurons (ESNs) into the host CNS tissue. Here, we use ES cells engineered to express… CONTINUE READING

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