Functional integration of a metabolic network model and expression data without arbitrary thresholding

@article{Jensen2011FunctionalIO,
  title={Functional integration of a metabolic network model and expression data without arbitrary thresholding},
  author={Paul A. Jensen and Jason A. Papin},
  journal={Bioinformatics},
  year={2011},
  volume={27 4},
  pages={541-7}
}
MOTIVATION Flux balance analysis (FBA) has been used extensively to analyze genome-scale, constraint-based models of metabolism in a variety of organisms. The predictive accuracy of such models has recently been improved through the integration of high-throughput expression profiles of metabolic genes and proteins. However, extensions of FBA often require that such data be discretized a priori into sets of genes or proteins that are either 'on' or 'off'. This procedure requires selecting… CONTINUE READING
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