Functional innervation of cultured hippocampal neurones by cholinergic afferents from co-cultured septal explants

@article{Gahwiler1985FunctionalIO,
  title={Functional innervation of cultured hippocampal neurones by cholinergic afferents from co-cultured septal explants},
  author={B. H. Gahwiler and David Brown},
  journal={Nature},
  year={1985},
  volume={313},
  pages={577-579}
}
The rat hippocampus receives a strong cholinergic innervation from the medial septum1–3; information about the development and function of this pathway could help to elucidate the mechan isms of memory functions4–6. Previous electrophysiological studies have shown that septal stimulation in vivo facilitates commissural7,8 and perforant path9 inputs and that stimulation of intra-hippocampal cholinergic fibres in vitro produces a slow depolariz ation of rat hippocampal CA3 pyramidal neurones and… CONTINUE READING

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