Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C.

Abstract

CYP2D6 is responsible for the oxidative metabolism of 20-25 % of clinical drugs and its genetic polymorphisms can significantly influence the drug metabolism. In this study, we analyzed the functional activities of four nonsynonymous single nucleotide polymorphisms from CYP2D6*52 allele, which were recently found, and one found frequently in CYP2D6 alleles… (More)
DOI: 10.1007/s12272-013-0212-5

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