Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies.

@article{Vzquez2012FunctionalIB,
  title={Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies.},
  author={Esther V{\'a}zquez and Jos{\'e} L Corchero and Joan F. Burgue{\~n}o and Joaqu{\'i}n Seras-Franzoso and Ana Kosoy and Ramon Bosser and Rosa Mendoza and Joan Marc Mart{\'i}nez-L{\'a}inez and Ursula Rinas and Ester Fern{\'a}ndez and Luis Ru{\'i}z-{\'A}vila and Elena Garcia-Fruit{\'o}s and Antonio Villaverde},
  journal={Advanced materials},
  year={2012},
  volume={24 13},
  pages={
          1742-7
        }
}
Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies. 

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