Functional inactivation of the WTX gene is not a frequent event in Wilms’ tumors


For many years the precise genetic etiology of the majority of Wilms’ tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately one-third of Wilms’ tumors. Moreover, in female cases, the somatically inactivated alleles were found to invariantly derive from the active… (More)
DOI: 10.1038/onc.2008.93


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