Functional inactivation of a transcriptional corepressor by a signaling kinase

@article{Barnes2003FunctionalIO,
  title={Functional inactivation of a transcriptional corepressor by a signaling kinase},
  author={Christopher J. Barnes and Ratna K. Vadlamudi and Sandip K. Mishra and Raymond H. Jacobson and Feng Li and Rakesh Kumar},
  journal={Nature Structural Biology},
  year={2003},
  volume={10},
  pages={622-628}
}
The C-terminal binding protein 1 (CtBP) is a ubiquitous corepressor linking the recruitment of DNA- and histone-modifying proteins to sequence-specific DNA-binding proteins and facilitating gene regulation during development and oncogenesis. We describe here the binding, phosphorylation and functional regulation of CtBP by the p21-activated kinase 1 (Pak1). Pak1 phosphorylates CtBP selectively on Ser158 within a putative regulatory loop, triggering CtBP cellular redistribution and blocking CtBP… 

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