Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.
@article{Cagli2011FunctionalIV, title={Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.}, author={Dejan Cagli{\vc} and Anja Globisch and Maik Kindermann and Ngee Han Lim and Volker Jeske and H. -P. Juretschke and Eckart Dr. Bartnik and Klaus Ulrich Dr. Weithmann and Hideaki Nagase and Boris Turk and Karl Ulrich Wendt}, journal={Bioorganic \& medicinal chemistry}, year={2011}, volume={19 3}, pages={ 1055-61 } }
42 Citations
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.
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- 2012
Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.
- Biology, ChemistryJournal of the American Chemical Society
- 2015
The design and synthesis of a near-infrared quenched activity-based probe (qABP) is presented that selectively targets cathepsin S which is highly expressed in immune cells and retained both in vitro and in vivo.
Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin
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This approach validates cathepsin B as a promising diagnostic and theranostic target in cancer and other inflammation-associated diseases.
In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate**
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- 2014
The lipidated probe provided a prolonged and strongly fluorescent signal in tumors when compared to the very similar non-lipidated probe, demonstrating that non-invasive tumor identification is feasable.
Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes.
- Biology, ChemistryCurrent opinion in chemical biology
- 2011
Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging.
- Medicine, BiologyRheumatology
- 2016
It is demonstrated that longitudinal non-invasive duplexed optical fluorescence imaging provides a simple assessment of arthritic disease activity within the joints of mice following the induction of CIA and may represent a powerful tool to monitor the efficacy of drug treatments in preclinical studies.
Detection of DSS-induced gastrointestinal mucositis in mice by non-invasive optical near-infrared (NIR) imaging of cathepsin activity
- Medicine, BiologyCancer biology & therapy
- 2013
The investigation suggests that NIR optical imaging can detect cathepsin-dependent probe cleavage non-invasively in animals with DSS-induced IBD, and could be coupled with colonoscopy investigation to aid in the sampling and the diagnostics of IBD.
Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages
- BiologyParticle and Fibre Toxicology
- 2016
This study shows that exposure to silica, alum and polystyrene particulates induces IL-1β release from macrophages, through lysosomal destabilization, and supports the emerging significance of CTSS as a regulator of the innate immune response.
Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe.
- Biology, ChemistryBiochimie
- 2019
Cysteine cathepsins and their potential in clinical therapy and biomarker discovery
- BiologyProteomics. Clinical applications
- 2014
This review will present cysteine cathepsin roles in disease progression and discuss their potential relevance as prognostic and diagnostic biomarkers.
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Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by…