Functional importance of the interhelical hydrogen bond between Thr204 and Tyr174 of sensory rhodopsin II and its alteration during the signaling process.

@article{Sudo2006FunctionalIO,
  title={Functional importance of the interhelical hydrogen bond between Thr204 and Tyr174 of sensory rhodopsin II and its alteration during the signaling process.},
  author={Yuki Sudo and Yuji Furutani and Hideki Kandori and John L Spudich},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 45},
  pages={
          34239-45
        }
}
Sensory rhodopsin II (SRII), a receptor for negative phototaxis in haloarchaea, transmits light signals through changes in protein-protein interaction with its transducer HtrII. Light-induced structural changes throughout the SRII-HtrII interface, which spans the periplasmic region, membrane-embedded domains, and cytoplasmic domains near the membrane, have been identified by several studies. Here we demonstrate by site-specific mutagenesis and analysis of phototaxis behavior that two residues… CONTINUE READING
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