Functional importance of synaptobrevin and SNAP-25 during exocytosis of histamine by rat gastric enterochromaffin-like cells.

@article{HhneZell1997FunctionalIO,
  title={Functional importance of synaptobrevin and SNAP-25 during exocytosis of histamine by rat gastric enterochromaffin-like cells.},
  author={Barbara H{\"o}hne-Zell and Annette B. Galler and Wolfgang Schepp and Manfred Gratzl and Christian Prinz},
  journal={Endocrinology},
  year={1997},
  volume={138 12},
  pages={5518-26}
}
Gastric enterochromaffin-like (ECL) cells release histamine upon stimulation with gastrin in a calcium-dependent manner. The intracellular mechanisms and proteins mediating exocytosis of histamine-containing vesicles in ECL cells have not been determined yet. We used immunocytochemistry to show the localization of SNAP-25 (synaptosome-associated protein of 25 kDa) and synaptobrevin VAMP (vesicle-associated membrane protein) in ECL cells of the rat gastric mucosa and in isolated, highly enriched… CONTINUE READING