Functional importance of apolipoprotein A5 185G in the activation of lipoprotein lipase.


BACKGROUND Apolipoprotein A5 (APOA5) over-expression enhances lipolysis of triglyceride (TG) through stimulation of lipoprotein lipase (LPL) activity; however, an APOA5 G185C variant was found associated with hypertriglyceridemia. The aim of this study was, therefore, to explore the importance of APOA5 185GG in the activation of LPL. METHODS A fragment… (More)
DOI: 10.1016/j.cca.2011.09.045