Functional importance of Dicer protein in the adaptive cellular response to hypoxia.

@article{Ho2012FunctionalIO,
  title={Functional importance of Dicer protein in the adaptive cellular response to hypoxia.},
  author={J J David Ho and Julie L. Metcalf and Matthew Yan and Paul J Turgeon and Jenny Jing Wang and Maria Chalsev and Tania N Petruzziello-Pellegrini and Albert K.Y. Tsui and Jeff Z He and Helena Dhamko and H. S. Jeffrey Man and Gregory B. Robb and Bin Tean Teh and Michael Ohh and Philip A. Marsden},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 34},
  pages={29003-20}
}
The processes by which cells sense and respond to ambient oxygen concentration are fundamental to cell survival and function, and they commonly target gene regulatory events. To date, however, little is known about the link between the microRNA pathway and hypoxia signaling. Here, we show in vitro and in vivo that chronic hypoxia impairs Dicer (DICER1) expression and activity, resulting in global consequences on microRNA biogenesis. We show that von Hippel-Lindau-dependent down-regulation of… CONTINUE READING