Functional implications of the noradrenergic-cholinergic switch induced by retinoic acid in NB69 neuroblastoma cells.


Some neuroblastoma cell lines change their neurotransmitter phenotype from noradrenergic to cholinergic under retinoic acid treatment. Such "neurotransmitter switch" seems to be a consequence of changes in the expression and activity of the biosynthetic machinery for both neurotransmitters. In this study, we have characterized this "neurotransmitter switch… (More)


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