Functional implications of burst firing and single spike activity in lateral geniculate relay neurons

@article{McCormick1990FunctionalIO,
  title={Functional implications of burst firing and single spike activity in lateral geniculate relay neurons},
  author={David A. McCormick and Hermann Feeser},
  journal={Neuroscience},
  year={1990},
  volume={39},
  pages={103-113}
}
Guinea-pig thalamocortical relay neurons can intrinsically generate action potentials in two distinct patterns: as high frequency bursts or as relatively independent single spikes. The burst firing mode is due to the presence of a low threshold Ca2+ current and imposes a marked non-linear transformation on depolarizing or hyperpolarizing inputs. In the burst firing mode, thalamic neurons respond to increasing frequencies of depolarizing inputs with progressively fewer action potentials such… CONTINUE READING

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