Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

@inproceedings{Yoshimizu2015FunctionalIO,
  title={Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons},
  author={Takao Yoshimizu and Jen Q. Pan and Alison E. Mungenast and J. Mark Madison and Susan C. Su and Josh K Ketterman and Dost Ongur and Donna L. McPhie and Bruce Cohen and Roy H. Perlis and Li-Huei Tsai},
  booktitle={Molecular Psychiatry},
  year={2015}
}
Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia and major depression, and a haplotype located in an intronic region of the L-type voltage-gated calcium channel (VGCC) subunit gene CACNA1C (peak associated SNP rs1006737), making it one of the most replicable and consistent associations in psychiatric genetics. In the… CONTINUE READING
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