Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation.

@article{Olsen2008FunctionalIF,
  title={Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation.},
  author={Michelle L Olsen and Harald Sontheimer},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 3},
  pages={589-601}
}
Astrocytes and oligodendrocytes are characterized by a very negative resting potential and a high resting permeability for K(+) ions. Early pharmacological and biophysical studies suggested that the resting potential is established by the activity of inwardly rectifying, Ba(2+) sensitive, weakly rectifying Kir channels. Molecular cloning has identified 16 Kir channels genes of which several mRNA transcripts and protein products have been identified in glial cells. However, genetic deletion and… CONTINUE READING

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