Functional impairment of bone formation in the pathogenesis of osteoporosis: the bone marrow regenerative competence.

@article{Bidwell2013FunctionalIO,
  title={Functional impairment of bone formation in the pathogenesis of osteoporosis: the bone marrow regenerative competence.},
  author={Joseph P. Bidwell and M. de Buergo Alvarez and Mark J Hood and Paul J. Childress},
  journal={Current osteoporosis reports},
  year={2013},
  volume={11 2},
  pages={117-25}
}
The skeleton is a high-renewal organ that undergoes ongoing cycles of remodeling. The regenerative bone formation arm ultimately declines in the aging, postmenopausal skeleton, but current therapies do not adequately address this deficit. Bone marrow is the primary source of the skeletal anabolic response and the mesenchymal stem cells (MSCs), which give rise to bone matrix-producing osteoblasts. The identity of these stem cells is emerging, but it now appears that the term 'MSC' has often been… CONTINUE READING
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