Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease.

@article{Borsook2004FunctionalIO,
  title={Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease.},
  author={David Borsook and Rami Burstein and Lino Becerra},
  journal={Journal of neurobiology},
  year={2004},
  volume={61 1},
  pages={107-25}
}
Peripheral inflammation or nerve damage result in changes in nervous system function, and may be a source of chronic pain. A number of animal studies have indicated that central neural plasticity, including sensitization of neurons within the spinal cord and brain, is part of the response to nervous system insult, and can result in the appearance of altered sensation, including pain. It cannot be assumed, however, that data obtained from animal models unambiguously reflects CNS changes that… CONTINUE READING

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