Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis.

@article{Sameni2003FunctionalIO,
  title={Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis.},
  author={Mansoureh Sameni and Julie Dosescu and Kamiar Moin and Bonnie F Sloane},
  journal={Molecular imaging},
  year={2003},
  volume={2 3},
  pages={
          159-75
        }
}
The underlying basement membrane is degraded during progression of breast and colon carcinoma. Thus, we imaged degradation of a quenched fluorescent derivative of basement membrane type IV collagen (DQ-collagen IV) by living human breast and colon tumor spheroids. Proteolysis of DQ-collagen IV by HCT 116 and HKh-2 human colon tumor spheroids was both intracellular and pericellular. In contrast, proteolysis of DQ-collagen IV by BT20 human breast tumor spheroids was pericellular. As stromal… CONTINUE READING

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