Functional imaging of human motor cortex at high magnetic field.

@article{Kim1993FunctionalIO,
  title={Functional imaging of human motor cortex at high magnetic field.},
  author={S. G. Kim and James Ashe and Apostolos P. Georgopoulos and Hellmut Merkle and Jutta M. Ellermann and Ravi S. Menon and Seiji Ogawa and K{\^a}mil Uğurbil},
  journal={Journal of neurophysiology},
  year={1993},
  volume={69 1},
  pages={
          297-302
        }
}
1. We used conventional gradient echo magnetic resonance imaging (MRI) at high field strength (4 Tesla) to functionally image the right motor cortex in six normal human subjects during the performance of a sequence of self-paced thumb to digit oppositions with the left hand (contralateral task), the right hand (ipsilateral task), and both hands (bilateral task). 2. A localized increase in activity in the lateral motor cortex was observed in all subjects during the task. The area of activation… 

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References

SHOWING 1-10 OF 45 REFERENCES

Neuronal activity in cortical motor areas related to ipsilateral, contralateral, and bilateral digit movements of the monkey.

TLDR
After extensive training, electromyographic studies revealed that muscle activities before the key press were limited to the digit and hand muscles of the limb instructed to move, and no overt increase or decrease in activity was detectable in the proximal limb or body muscles in relation to the key-press movements or instructions.

Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.

  • S. OgawaD. Tank K. Uğurbil
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo

The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography

TLDR
The results suggest that ipsilateral motor pathways may play a role in the recovery of motor function after ischemic stroke.

Regional cerebral blood flow during voluntary arm and hand movements in human subjects.

TLDR
The data indicate that neither "fractionation" nor distal movement per se cause selective activation of sensorimotor cortex, and this finding does not prove unequivocally a "selective" role of the nonprimary motor areas in proximal movement.

Different cortical areas in man in organization of voluntary movements in extrapersonal space.

TLDR
It is concluded that the supplementary motor areas, which are also active during programming and execution of movement sequences in intrapersonal space (33), elaborate programs for motor subroutines necessary in skilled voluntary motion are concluded.

Supplementary motor area and other cortical areas in organization of voluntary movements in man.

TLDR
It is suggested that the supplementary motor areas are programming areas for motor subroutines and that these areas form a queue of time-ordered motor commands before voluntary movement are executed by way of the primary motor area.

Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.

Neuronal activity causes local changes in cerebral blood flow, blood volume, and blood oxygenation. Magnetic resonance imaging (MRI) techniques sensitive to changes in cerebral blood flow and blood

The relationship of corpus callosum connections to electrical stimulation maps of motor, supplementary motor, and the frontal eye fields in owl monkeys

TLDR
The somatotopic organization of M‐I was neither a single topographic representation, nor two serial or mirror symmetric representations, nor a “nesting about joints” representation, and is more adequately described as a mosaic of regions, each representing movements of a restricted part of the body, with multiple representations of movements that tend to be somatOTopically related.

Impairment and recovery of ipsilateral sensory-motor function following unilateral cerebral infarction.

TLDR
The data suggest that all cerebral hemisphere areas involved in S-M functions can exert some degree of bilateral motor control, and that the proportion of ipsilateral to contralateral control is closely related to the degree of continuous sensory feedback required by the particular task.

Time course EPI of human brain function during task activation

Using gradient‐echo echo‐planar MRI, a local signal increase of 4.3 ± 0.3% is observed in the human brain during task activation, suggesting a local decrease in blood deoxyhemoglobin concentration